On-Site Liquid Nitrogen Production: 10 Competitive Advantages with Allum Machines

Orlando-FL, December 22, 2025.

Allum Corp. Technical Support Department

Prepared by: Eng. Josmar M. Vasconcelos

Production of Liquid Nitrogen in Clinics, Laboratories and Hospitals.

Independence and Quality Assurance

The use and application of liquid nitrogen (LN2) have grown widely in the world in various segments, forcing companies and users to start their own production due to the scarcity of the product and the considerable increase in consumption and final price. In hospitals, laboratories and medical centers, LN2 is being widely used for cryotherapies and cryosurgeries, freezing of human tissues, removal of abnormal tissues, such as warts, skin lumps, tumors and tissues with tendencies to evolve to cancer. It is also used to preserve biological samples such as blood, sperm, and embryos, due to its extremely low temperature in the order of -196°C.

Healthcare professionals rely on liquid nitrogen (LN2) in a wide range of therapeutic and clinical applications. Its ability to provide precise, localized freezing makes it indispensable in various specialties.

Applications and uses of LN2 in clinics and hospitals:

·In dermatology, the common use is to freeze skin lesions, replace skin with dead cells, treat warts, actinic keratoses, skin lumps and some types of skin cancer.

·Storage of biological materials (sperm, ovum, embryos, blood samples, bone marrow) for long-term preservation.

·Cryo-massages with the application of Liquid Nitrogen in the form of steam on the skin, scalp stimulate collagen production and growth of hair follicles.

·In surgery, changing its physical state from liquid to gaseous with very low humidity and high pressure, used as a source to power pneumatic surgical equipment in orthopedic procedures and neurosurgery, ensuring cleanliness and safety.

·It is used to cool surgical carbon dioxide lasers, to cool MRI components and other sensitive equipment such as superconducting magnets ensuring optimal performance for high-resolution imaging.

·Sterilization with LN2 for delicate instruments and biological materials. Its extreme cold can deactivate pathogens without harsh chemicals, preserving the integrity of the instruments

·Process of scarring and formation of new tissues after LN2 application.

Medical Grade:

The liquid nitrogen used in clinics, laboratories and hospitals must be medical grade LN2 with guaranteed purity and safety and meet pharmaceutical and health standards. Industrial LN2 cannot be used for medical applications, as there may be contaminations that affect the patient's health and the integrity of the samples.

The use of Liquid Nitrogen is not limited to the skin, but it can also be used on internal organs in treatments of abnormal cells and tumors within the body that cannot be safely extracted in surgical procedures on the liver, kidney, lungs, breast, cervix, prostate, bones and also in processes of freezing and thawing of abnormal cells and eye treatment.

Producing Cryogenic LN2:

The supply of Liquid Nitrogen is a concern in the medical industry, in addition to the growing demand for the product by clinics, laboratories and the hospital medical network for various applications, the product must have a guarantee of 99.99% purity and be constantly tested.

For medical application, it is not advisable to store large quantities of LN2 in cryogenic cylinders, because liquid nitrogen must be at very low temperatures (-196°C) and just above this temperature it starts the process of evaporation and formation of nitrogen gas and excessive pressure increase, losing a lot of material, making it difficult to store and there may also be oxygenation and lower the purity of the product.

In addition to not having the guarantee of purity after long-term storage, it is also dangerous to handle and store liquid nitrogen. Some companies offer equipment that monitors the quality and purity of LN2 and can be installed in dewars and tanks. However, the signaling of low-purity nitrogen is nothing more than proof of a low-quality of the product that can contaminate patients and samples, and this product must be completely discarded.

To control purity, companies are opting for their own production of liquid nitrogen. Companies linked to the field of cryogenic products and laboratories such as Allum Corporation, are currently producing and customizing equipment in the hospital medical line to produce liquid nitrogen, according to customer demand. VisitAllum Corp

The "liquefiers" equipment that produces N2 through a PSA and converts it to its liquid form, produces the material in the amount required by customers with instant control of the purity of 99.99%. The production of LN2 comes from the local air, in a system of filtration, compression and separation of gases, where it makes its production possible within the customer's facilities and close to the end user. Allum's In-door liquefiers can be produced with capacities from 10 to 300 liters of nitrogen per day.

Far from being a power plant, liquefiers are modern equipment, electronically processed and controlled, and instantaneous measurement of product purity. LN2 is released from the liquefier only after purity measurement and when it reaches 99.99%. Machines for medical use, free of oil or non-ecological contaminants, low noise, easy to handle and can be modular depending on the production demand and customer need.

These machines have been taking their space in the medical environment, hospitals, clinics and laboratories because they are compact and built on wheels, which can be moved in different rooms and floors of buildings, with just one point of energy to start producing liquid nitrogen.

United States Department of Veterans Affairs

Companies with high quality standards in their experiments and services are already adapted to this reality and currently produce their own LN2 and are no longer dependent on suppliers. A recent Allum success story is the U.S. Department of Veterans Affairs (VA) which purchased three of our ACLN2-10A machines with a production capacity of 10 liters of Liquid nitrogen per day. O VA is a federal cabinet-level agency, charged with providing lifelong healthcare services to eligible military veterans at the 170 VA medical centers and outpatient clinics located throughout the country, that provides a wide range of benefits, healthcare, and support services to military veterans, their families, and survivors, fulfilling a promise to care for those who served in the armed forces.

It administers the largest integrated health system in the U.S. and offers disability compensation, education, housing assistance, life insurance, and burial benefits through its main components: the Veterans Health Administration (VHA), Veterans Benefits Administration (VBA), and National Cemetery Administration (NCA). Youngstown, Oh VA Medical Center unit.

More than simply producing LN2, the VA is concerned with the quality of its healthcare services and its patients and has the production of LN2 for its units on demand for the product.

Integrating LN2 into the workflows of doctors, nurses, scientists, and other employees requires careful planning. Staff must be trained to handle cryogenic liquids in a safe manner and compliance with standards is critical. Procedures for the use of LN2 must follow safety standards established by agencies such as the FDA and OSHA, the final product must have proper storage, ventilation and emergency protocols that are essential to prevent accidents. As employees are trained and follow LN2 compliance regulations and requirements, use becomes safer and more effective in healthcare settings.

In addition to the technical commissioning and programming of the machines, Engineer Josmar Vasconcelos, Allum's Technical Support manager, gave training on the operation and maintenance of the machines to the group of administrators and nurses of the VA medical center.

Employees were trained to operate the liquefyer, produce and extract liquid nitrogen, and return to normal LN2 production operation. The training also aims at the physical safety of people and the risks and basic care necessary for the handling of LN2 and the use of protective equipment were explored.

The business continuity of our customers and their services using and applying LN2 is guaranteed production by themselves without the need for third parties. Allum also offers a remote and local technical support service for the installation of machines, employee training, operation and maintenance of equipment and software.

However, the choice in the production of LN2 itself is a decision of the customer.

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